Our groups maintain fragment libraries in the following aspects:ġ.We carry out regular identity, solubility, and purity determination.Ģ.Our fragment libraries are equipped with automated smart pooling.ģ.We perform positive control at regular intervals.Ĥ.We are capable of conducting diversity analysis. We have developed our fragment libraries under the principle of 'rules of three' and our fragment libraries are composed of lead-like fragment libraries, high solubility fragment libraries, drug-fragment libraries and 3D-fragment-libraries. The fragment libraries for screening can be provided by BOC Sciences or our clients. Our Fragment-Based Screening Capabilities We can identify fragment hits from our well-designed compound libraries using multiple screening approaches which covers advanced biophysical detection instruments, and the identified hit can be then grown into drug-like molecules through various strategies in the fragment-to-lead process. The designed drugs through fragment-based screening have pharmacological activity and selectivity.Īt BOC Sciences, our teams have developed a fragment-based screening platform for your early drug discovery. The compound structure is simple and easy to bind to the target protein, which also benefits the structural modification in the lead optimization process. 2020) Advantages of Fragment-Based Screeningįragment-based screening reduces the molecular size of the chemical compounds and the 'fragment space' is smaller than the 'chemical space', which allows for screening relatively small library with greater chemical space.įragment libraries usually have low chemical complexity and show higher binding efficiency compared to larger elaborated drug-like ligands.
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